Mammalian Genomics

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Anatoly Ruvinsky and Jennifer A Marshall Graves

Hardback

December 2004

9780851999104

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$399.25

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Genomics has experienced a dramatic development during the last 15-20 years. Data from mammalian genomes such as the human, mouse and rat have already been published, while others such as the dog, cattle and chimpanzee will soon follow. This book summarizes the current knowledge of mammalian genomics and offers a comparative analysis of genomes known today. This analysis includes farm, companion and lab animals. Topics covered include structural and functional aspects of the mammalian genome, mechanisms of genomic changes at the molecular level, evolution of DNA sequences, comparative chromosome mapping and painting, genome databases, gene prediction and the use of genomic information to understand inherited diseases. Contributors include leading researchers from Europe, USA, Australia and Japan.

"The scientific content of this book is of staggering proportions... As such this book is likely to prove very popular and become a highly useful resource."
- Biologist

Part 1. Organization of the Mammalian Genome
* Linkage mapping
* Mapping genomes at the chromosome level
* Mapping genomes at the molecular level
* DNA sequence of the human and other mammalian genomes

Part 2. Expression of the Mammalian Genome
* The transcriptome
* The proteome
* The epigenome - epigenetic regulation of gene expression in mammalian species
* Regulation of genome activity and genetic networks in mammals
* Inducing alterations in the mammalian genome for investigating the function of genes

Part 3. Evolution of the Mammalian Genome
* Mammalian genomes in context
* Elements and mechanisms of genome change
* DNA sequence evolution and phylogenetic footprinting
* The evolution of the mammalian karyotype
* Comparative gene mapping and chromosome painting in mammals and the reconstruction of the ancestral mammalian karyotype

Part 4. Genome Analysis and Bioinformatics
* Bioinformatics: from computational analysis through to integrated systems
* Genetic databases
* Gene predictions and annotations

Part 5. The Fruits of Mammalian Genomics
* Genomic research and progress in understanding inherited disorders in humans and other mammals
* Pharmacogenomics
* Genome scanning for quantitative trait loci
* Mammalian population genetics and genomics

Anatoly Ruvinsky

Anatoly Ruvinsky Since graduation from Novosibirsk State University (Russia) in 1969, A. Ruvinsky has been working in several fields of genetics for more than 40 years. He received his PhD in 1974 and Dr.Sc. in 1985. In 1986, Ruvinsky was elected as head of laboratory of animal genetics and 1988 as Vice Director of the Institute of Cytology and Genetics of Russian Academy of Sciences. In 1993, he joined the University of New England, Australia. Professor Ruvinsky published more than 100 refereed papers in leading genetic journals and edited 11 books so far. This includes the series of books on mammalian genetics, which currently undergoes 2nd edition. His most recent book, Genetics and Randomness, was published in 2009.

Jennifer A Marshall Graves

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